Unilateral Carotid Body Resection in Resistant Hypertension: A Safety and Feasibility Trial.

نویسندگان

Krzysztof Narkiewicz

Laura E K Ratcliffe

Emma C Hart

Linford J B Briant

Marzena Chrostowska

Jacek Wolf

Anna Szyndler

Dagmara Hering

Ana P Abdala

Nathan Manghat

Amy E Burchell

Claire Durant

Melvin D Lobo

Paul A Sobotka

Nikunj K Patel

James C Leiter

Zoar J Engelman

Angus K Nightingale

Julian F R Paton

چکیده

Animal and human data indicate pathological afferent signaling emanating from the carotid body that drives sympathetically mediated elevations in blood pressure in conditions of hypertension. This first-in-man, proof-of-principle study tested the safety and feasibility of unilateral carotid body resection in 15 patients with drug-resistant hypertension. The procedure proved to be safe and feasible. Overall, no change in blood pressure was found. However, 8 patients showed significant reductions in ambulatory blood pressure coinciding with decreases in sympathetic activity. The carotid body may be a novel target for treating an identifiable subpopulation of humans with hypertension.

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